Alteraciones genéticas en la vía canónica Wnt/β-catenina en cáncer colorrectal
نویسندگان
چکیده
The goal of this study is to better understand the complexity canonical Wnt/β-catenin (C-WNT) signaling pathway in colorectal cancer (CRC): how it works, its key mutations and novel therapeutic compounds under development. PubMed, Scopus SciELO were used find most relevant medical literature on issue. C-WNT regulates essential cellular biological processes: genetic changes are significant contributors CRC. Wnt ligand binding Frizzled receptor low-density lipoprotein receptor-related protein 5 or 6 (LRP5/6) stimulates pathway; extracellular membrane ternary complex activates kinases that promote phosphorylation intracellular domain LRP5/6 starts cell cascade. changed more than 90 % all CRCs, with adenomatous polyposis coli gene showing great majority type cancer. In recent years, has been an important target for researching new treatments; various inhibitors (monoclonal antibodies, inhibitory proteins, selective small other families) have developed treatment CRC, being them still preclinical phases. conclusion, CRC related pathway, whose persistent activation provides cells self-renewing growth capabilities linked resistance There active research innovative affect however, none received commercial approval so far.
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ژورنال
عنوان ژورنال: Horizonte Médico
سال: 2022
ISSN: ['2227-3530', '1727-558X']
DOI: https://doi.org/10.24265/horizmed.2022.v22n4.14